Nena J. Winand, DVM, PhD

Department of Molecular Medicine

 

College of Veterinary Medicine
Cornell University
Ithaca, New York 14853

EDUCATION:

1979 The Pennsylvania State University, University Park, Pennsylvania, B.S., Animal Science.

1981 The Pennsylvania State University, University Park, Pennsylvania, M.S., Veterinary Science.

1986 Iowa State University, Ames, Iowa, D.V.M., Veterinary Medicine.

1994 Cornell University, Ithaca, New York, Ph.D., Pathobiology.

PROFESSIONAL EXPERIENCE:

1979-1981 Graduate Student in Veterinary Science, Department of Veterinary Science, The Pennsylvania State University. Dr. Arian Zarkower, M.S. thesis advisor.

1981-1986 Veterinary Student, Iowa State University, Ames, Iowa.
1985-1986 Veterinary pathology preceptorships, completed on a rotating basis:
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania. Dr. Michael Goldschmidt, supervisor.
New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania. Dr. Helen M. Acland, supervisor.

Division of Comparative Medicine and Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Dr. John Strandberg, supervisor.

Animal Disease Laboratory, Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania. Dr. Terrance Wilson, supervisor.
1986-1987 Residency in Anatomic Pathology, Department of Pathology, College of Veterinary Medicine, Cornell University, Ithaca, New York.

1987-1994 Graduate Student, Department of Pathology, College of Veterinary Medicine, Cornell University, Ithaca, New York. Professor Barry Cooper, Ph.D. thesis advisor.
1994-1995 Postdoctoral Associate, laboratory of Professor Robert Oswald, Department of Pharmacology, College of Veterinary Medicine, Cornell University, Ithaca, New York.
1995-1998 Assistant Professor, Department of Pathology, College of Veterinary Medicine, Cornell University, Ithaca, New York.
1995-1996 Visiting Assistant Professor, laboratory of Professor Richard Kolodner, Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.

1998-2004 Assistant Professor, Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York.

2004-Present Senior Research Associate, Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York.

RESEARCH INTERESTS:

Medical and comparative genetics, with emphasis on performance and production traits in horses and cattle.

HONORS AND AWARDS:

1983-1986 Iowa State University High Scholarship Student
1983-1986 College of Veterinary Medicine Challenge Fund Award for Academic Excellence; class rank 1 1983, 1984; class rank 2 1985, 1986
1986 D.V.M. with distinction, Iowa State University College of Veterinary Medicine
Phi Kappa Phi, Sigma Xi, Phi Zeta, Gamma Sigma Delta
PATENTS:
 
“A Method for Detection of Alterations in MSH5” PCT/US98/13850 and 60/051,686. Provisional filing July 3, 1997. International filing July 2, 1998.
 
PUBLICATIONS:
 
Woode, G.N., Mohammed, K.A., Saif, L.J., Winand, N.J., Quesada, M., Kelso, N.E., and Pohlenz, J.F. (1983) Diagnostic methods for the newly discovered “Breda” group of calf enteritis inducing viruses. Proceedings of the Third International Symposium, World Association of Veterinary Laboratory Diagnosticians 2: 533-538.

Woode, G.N., Saif, L.J., Quesada, M., Winand, N.J., Pohlenz, J.F., and Gourley, N.K. (1985) Comparative studies on three isolates of Breda virus of calves. Am. J. of Vet. Res. 46: 1003-1010.

Cooper, B.J., Winand, N.J., Stedman, H., Valentine, B.A., Hoffman, E.P., Kunkel, L.M., Oronzi-Scott, M., Fischbeck, K., Kornegay, J., Avery, R.J., Williams, J.R., Schmickel, R.D., and Sylvester, J.E. (1988) The homologue of the Duchenne locus is defective in X-linked muscular dystrophy of dogs. Nature 334: 154-156.
Cooper, B.J., Gallagher, E.A., Smith, C.A., Valentine, B.A., and Winand, N.J. (1990) Mosaic expression of dystrophin in carriers of canine X-linked muscular dystrophy. Lab. Invest. 62: 171-178.

Cooper, B.J., Valentine, B.A., Winand, N.J., and Huxtable, C.R. (1990) The xmd dog as a model of Duchenne muscular dystrophy. Proceedings of the XIth International Congress of Neuropathology, Kyoto, Japan. pp 552-553.

Valentine, B.A., Winand, N.J., Pradhan, D., Moise, N.S., de Lahunta, A., Kornegay, J.N., and Cooper, B.J. (1992) Canine X-linked muscular dystrophy as an animal model of Duchenne muscular dystrophy: A review. Am. J. Med. Genet. 42: 352-356.

Winand, N.J., Edwards, M., Pradhan, D., and Cooper, B.J. (1994) Deletion of the dystrophin muscle promoter in feline muscular dystrophy. Neuromusc. Disord. 4: 433-445.

Barlett, R.J., Winand, N.J., Secore, S.L., Singer, J.T., Fletcher, S., Wilton, S., Bogan, D.J., Metcalf-Bogan, J.R., Bartlett, W.T., Howell, J.M., Cooper, B.J., and Kornegay, J.N. (1996) Mutation segregation and rapid carrier detection of X-linked muscular dystrophy in dogs. Am. J. Vet. Res. 57: 650-654.

Trepanier, L.A., Ray, K., Winand, N.J., Spielberg, S.P., and Cribb, A.E. (1997) Cytosolic arylamine N-acetyltransferase deficiency in the dog and other canids due to an absence of NAT genes. Biochem. Pharmacol. 54: 73-80.

Winand, N.J., Panzer, J.A., and Kolodner, R.D. (1998) Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene. Genomics 53: 69-80.

Edelmann, W., Cohen, P.E., Kneitz, B., Winand, N., Lia, M., Heyer, J., Kolodner, R., Pollard, J.W., and Kucherlapati, R. (1999) Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat. Genet. 21: 123-127.

Borges, A., Villaroel, Winand, N.J., Becemberg, Alfonzo, M., and Alfonzo, R. (2001) Molecular and biochemical characterization of a B-type NP guanylyl cyclase in bovine trachael smooth muscle. Am. J. Resp. Cell Mol. Biol. 25: 1-6.

Calero, M., Winand, N.J. and Collins, R.N. (2002) Identification of the novel proteins Yip4p and Yip5p as Rab GTPase interacting factors. FEBS Lett. 515: 89-98.

Calero, M., Chen, C.Z., Zhu, W., Winand, N., Havas, K.A., Gilbert, P.M., Burd, C.G. and Collins, R.N. (2003) Dual prenylation is required for Rab protein localization and function. Mol. Biol. Cell 14: 1852-1867.

Rishniw, M., Barr, S.C., Simpson, K.W., Winand, N., Wootton, J.A. (2004) Cloning and sequencing of the canine and feline cardiac troponin I genes. Am. J. Vet. Res. 65: 53-58.

Borges, A., Alfonzo, M.J., Garcia, C.C., Winand, N.J., Leipold, E., and Heinemann, S.H. Isolation, molecular cloning, and functional characterization of a novel beta-toxin from the Venezualan scorpion, Tityus zulianus. Toxicon 43 (6): 671-684, 2004.

Rashmir-Raven, A.M., Winand, N.J., Read, R.W., Hopper, R.M., Ryan, P.L., Poole, H.M., and Erb, H.N. Equine Hyperelastosis Cutis Update. Am. Assoc. Equine Pract., 50: 47-50, 2004.

Calero, M., Winand, N.J., Wills, E., Novick, P.J., and Collins, R.N. Yip1p and related proteins are pleiotropic Rab-interacting factors. Mol. Biol. Cell, in press, 2004.

Liang, L., Winand, N.J., and Baines, J.D. The UL31 protein of Herpes simplex virus 1 recruits thyroid receptor interacting protein 6 (TRIP6) to nuclear membranes of infected cells. In preparation.
 
Minor, R.R., Chu, M-L., Pulkkinen, L., Winand, N.J. and Uitto, J. (2004) Alternative splicing of Exon 64 of COL5A1 mRNA Coding for the C-propeptide of the 1(V) Collagen Chain Canine, Mouse and Human. In preparation.